Loup Loup Creek begins around the northern end of Buck Mountain and to the west of Ruby Hill. It continues down between Neville Ridge (west side of Wright Mountain) and Ritchie Ridge (east side of Buck Mountain). It travels south and around Cook Mountain where it travels under State Route 20. From Cook Mountain Loup Loup Creek twists between Fox Mountain and Chiliwist Butte where it finally heads south towards the town of Malott. The creek runs along the east side of Malott before flowing into the Okanogan River.